| 夏湘勤,黄彩红,席北斗,檀文炳,唐朱睿.畜禽粪便中氟喹诺酮类抗生素的生物转化与机制研究进展[J].农业环境科学学报,2019,38(2):257-267. |
| 畜禽粪便中氟喹诺酮类抗生素的生物转化与机制研究进展 |
| Review on biotransformation and mechanism of fluoroquinolone antibiotics from livestock manure |
| 投稿时间：2018-03-01 修订日期：2018-07-03 |
| DOI：10.11654/jaes.2018-0268 |
| 中文关键词: 氟喹诺酮 畜禽粪便 生物转化 机制 |
| 英文关键词: fluoroquinolone livestock manure biotransformation mechanism |
| 基金项目:国家自然科学基金青年科学基金项目（51508540） |
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| 中文摘要: |
| 氟喹诺酮类抗生素（FQs）是广泛应用于畜牧养殖业的兽药之一，可随畜禽粪便进入环境，危害人类健康与环境安全。堆肥和外源添加高效降解菌剂是高效、绿色的抗生素处理方法，可有效降低FQs在环境中的生态风险。目前，国内相关研究主要集中于FQs生物去除效率方面，而对其生物转化机理与影响因素研究较少。本文概述了国内外FQs的降解条件、降解途径、降解产物及残留抗菌活性等生物转化研究，重点阐述了FQs的生物转化机制，并对FQs生物转化研究进行了展望，为FQs的高效生物降解与转化、畜禽粪便资源化安全利用提供理论基础和技术支撑。 |
| 英文摘要: |
| Fluoroquinolone antibiotics (FQs)are veterinary drugs widely used in the livestock husbandry, which can enter the environment with livestock manure and increase the potential for adverse human health impacts and environmental safety. Composting and applying exogenously with efficient degrading bacterium inoculation are considered efficient and green method to remove antibiotics, which reduce the ecological risk of FQs to a minimum level in the environment. Although previous work provided focuses on the remove degradation of FQs, the mechanisms and effect factors of FQs biotransformation have not been studied. In this review article, we highlight the biotransformation of FQs, including degradation conditions, degradation pathways, degradation products and relative residual antibacterial activity. The biotransformation mechanisms of FQs were discussed in detail, and the direction of biotransformation of FQs was also proposed. Overall, this review may provide theoretical basis and technical support for the efficient biodegradation and transformation of FQs and the safe application of livestock manure as resources. |
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