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| Joint toxicity of atrazine and fluorene on zebrafish embryos |
| Received:March 04, 2021 |
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| KeyWord:atrazine;fluorene;zebrafish;amino acid metabolomics;joint toxicity |
| Author Name | Affiliation | E-mail | | WANG Beinan | Institute of Agricultural Quality Standards and Testing Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agricultural Product Quality and Safety, Ministry of Agriculture and Rural Affairs, Beijing 100081, China | | | SONG Xiao | Institute of Agricultural Quality Standards and Testing Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agricultural Product Quality and Safety, Ministry of Agriculture and Rural Affairs, Beijing 100081, China | | | HE Linjuan | Institute of Agricultural Quality Standards and Testing Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agricultural Product Quality and Safety, Ministry of Agriculture and Rural Affairs, Beijing 100081, China | | | QIAN Yongzhong | Institute of Agricultural Quality Standards and Testing Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agricultural Product Quality and Safety, Ministry of Agriculture and Rural Affairs, Beijing 100081, China | | | QIU Jing | Institute of Agricultural Quality Standards and Testing Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agricultural Product Quality and Safety, Ministry of Agriculture and Rural Affairs, Beijing 100081, China | qiujing@caas.cn |
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| Abstract: |
| To study the combined toxicity effects of atrazine and fluorene, zebrafishes were used as model organisms to carry out embryo development exposure experiments, combined toxicity model prediction, and targeted amino acid metabolomics research. The results showed that abnormal development was observed in zebrafish larvae after 120 h of joint exposure, leading to abnormal embryo yolk sac and curvature of the spine. The toxic action modes exhibited antagonistic and synergistic effects. Regardless of doses, the dual combined exposure had a higher risk of toxicity than single exposure. Targeted metabolomic studies found that pollutants mainly affect the amino acid metabolism of zebrafish larvae by interfering with the metabolism of glycine, serine, threonine, and histidine. The study showed that the combined exposure of atrazine and fluorene might interfere with physiological functions of zebrafish embryos, such as neural development, oxidative stress, anti-inflammatory mechanisms, energy metabolism, and immunity and apoptosis mechanisms, which in turn affects growth and development, with abnormal yolk sac being an indicator of toxicity. |
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