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| Bioaccumulation of metoprolol in the presence of oxide nanoparticles |
| Received:August 14, 2021 |
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| KeyWord:oxide nanoparticle;metoprolol;carp;bioaccumulation;adsorption/desorption |
| Author Name | Affiliation | E-mail | | LU Yuan | College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Nankai University, Tianjin 300350, China | | | SONG Qi | Panjin Campus of School of Foreign Languages, Dalian University of Technology, Panjin 124221, China | | | XU Jiayao | College of Environment, Shenyang University, Shenyang 110044, China | | | SUN Hongwen | College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Nankai University, Tianjin 300350, China | sunhongwen@nankai.edu.cn |
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| Abstract: |
| To reveal the effect of oxide nanoparticles(NPs) on the bioaccumulation of ionic organic pollutants in aquatic organisms, the effects of two typical oxide NPs on the enrichment and distribution of the β-blocker metoprolol were investigated in carp(Cyprinus carpio). The relationship between adsorption/desorption and bioaccumulation was also examined through batch equilibrium experiments. At the end of the uptake phase, the bioconcentration factor(BCF) value had increased by 2.39 times(TiO2 NPs) and 3.49 times(SiO2 NPs). In the depuration phase, the half-life of metoprolol decreased from 20.09 d to 8.39 d(TiO2 NPs) and 6.13 d(SiO2 NPs). At the end of depuration, the residual concentration of metoprolol in carp increased slightly in the presence of NPs. Co-exposure to various types of NPs did not alter the method of metoprolol uptake by the carp; however, it did significantly increase the concentration of metoprolol in their gills and viscera. SiO2 NPs exhibited a stronger and irreversible adsorption capacity for metoprolol compared to TiO2 NPs; the lg K F values fitted by the Freundlich model were 2.21(TiO2 NPs) and 4.47(SiO2 NPs) respectively. Our results indicate that the presence of NPs promote the bioaccumulation of metoprolol in carp though sorption. Adsorbed metoprolol enters the body of the fish mainly via feeding and gill respiration; however, it is not completely desorbed or absorbed by the carp. Some associated metoprolol may be directly depurated from the body with the discharge of NPs. |
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