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| Single and combined toxicity of heavy metals and tetracyclines to luminescent bacteria |
| Received:June 28, 2023 |
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| KeyWord:heavy metal;tetracycline antibiotics;toxicity unit method;concentration addition model;independent action model |
| Author Name | Affiliation | E-mail | | YIN Shuzheng | College of Biological Science and Technology, Hunan Agricultural University, Changsha 410028, China | | | LIU Gang | College of Biological Science and Technology, Hunan Agricultural University, Changsha 410028, China | | | FANG Jun | College of Biological Science and Technology, Hunan Agricultural University, Changsha 410028, China | fangjun1973@hunau.edu.cn |
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| Abstract: |
| In this study, the acute single toxicity and combined toxicity of five heavy metals and tetracycline antibiotics on luminescent bacteria were studied by a luminescent test. The toxicity unit method was used to characterize the combined toxicity, and the concentration addition model and independent action model were used to predict the combined acute toxicity of the binary mixed system to luminescent bacteria. The results showed that the toxicity was in the order of Pb(NO3)2>ZnSO4·7H2O>CdCl2·2H2O>oxytetracycline hydrochloride> chlortetracycline hydrochloride>doxycycline hydrochloride>tetracycline hydrochloride>CuSO4·5H2O>K2Cr2O7. The combined toxicity of heavy metals was mainly manifested as a synergistic effect. The combined toxicity of heavy metals and tetracycline antibiotics was mainly manifested as an additive and antagonistic effect, and the combined toxicity of tetracycline antibiotics was mainly manifested as an antagonistic effect. When heavy metals coexist with tetracycline antibiotics, they had different toxic effects on luminescent bacteria. Therefore, the combined toxic effects should be considered during the evaluation of combined environmental pollution. |
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