| 桑文才,李金阳,林嫣然,李士伟,高卫东,韩雪梅.南四湖沉积物抗生素的组成特征和环境风险[J].农业环境科学学报,2024,43(7):1609-1620. |
| 南四湖沉积物抗生素的组成特征和环境风险 |
| Composition profile and environmental risks of antibiotics in sediments of Nansi Lake |
| 投稿时间：2023-08-13 |
| DOI：10.11654/jaes.2023-0657 |
| 中文关键词: 抗生素 生态风险 抗性发展风险 沉积物 南四湖 |
| 英文关键词: antibiotic ecological risk resistance development risk sediment Nansi Lake |
| 基金项目:山东省自然科学基金项目（ZR2023MC159，ZR2022MD010）；山东省高等学校“青创团队计划”项目（2022KJ099） |
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| 中文摘要: |
| 为保障南四湖生态安全和周边居民健康，在汛后和汛前对南四湖沉积物中大环内酯类、四环素类、喹诺酮类、β-内酰胺类、磺胺类和氯霉素类抗生素进行测定，分析其组成特征，并评估其潜在的环境风险。结果表明：抗生素总含量在2.72~276.07 ng·g-1之间，平均含量较高的有喹诺酮类的氧氟沙星（11.67 ng·g-1）、恩诺沙星（4.96 ng·g-1）、环丙沙星（3.80 ng·g-1）、诺氟沙星（3.60 ng·g-1）和四环素类的氧四环素（6.40 ng·g-1）、金霉素（2.34 ng·g-1）。此外，大环内酯类的一些抗生素检出率较高，其中洁霉素和罗红霉素的检出率为100%。抗生素组成在汛后和汛前具有显著差异（Adonis test，P＜0.01），汛后抗生素的含量和种类数（48.21 ng·g-1，27种）均高于汛前（32.08 ng·g-1，23种）；而上级湖和下级湖间的抗生素组成无显著差异，但在不同采样位点间变化较大。风险熵值分析表明，氧氟沙星、环丙沙星、氧四环素和洁霉素同时具有较高的生态风险和抗生素抗性发展风险，且一些低或无生态风险的抗生素（如诺氟沙星和氯霉素）也可能产生较高的抗生素抗性发展风险。 |
| 英文摘要: |
| To ensure the ecological security of Nansi Lake and the health of the surrounding residents, antibiotics categorized into macrolides, tetracyclines, quinolones, β-lactams, sulfonamides, and chloramphenicol antibiotics were determined in the sediments of the lake before and after the flood. The composition profiles and potential environmental risks of the antibiotics were also analyzed and evaluated. The results showed that the total concentrations of antibiotics ranged from 2.72 ng·g-1 to 276.07 ng·g-1. The antibiotics with high average concentration were mainly classified as quinolones, including ofloxacin（11.67 ng·g-1）, enrofloxacin（4.96 ng·g-1）, ciprofloxacin （3.80 ng·g-1）, and norfloxacin（3.60 ng·g-1）, and tetracyclines, including oxytetracycline（6.40 ng·g-1）and chloromycin（2.34 ng·g-1）. Moreover, high detection rates were found for some macrolide antibiotics, such as lincomycin and roxithromycin, which had a detection rate of 100%. There was a significant difference in antibiotic profiles between after and before the flood（Adonis test, P＜0.01）. Both the concentration and number of antibiotics were higher after the flood（48.21 ng·g-1, 27 species）than before the flood（32.08 ng ·g-1, 23 species）. There was no significant difference in antibiotic profile between the superior lake and subordinate lake, although large variation was observed among different sampling sites. Based on the risk quotients, ofloxacin, ciprofloxacin, oxytetracycline, and lincomycin were at high ecological risk and high resistance development risk. Some other antibiotics such as norfloxacin and chloramphenicol might pose a high resistance development risk. |
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