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| Ecotoxicity of Single and Combined Contamination of 5-fluorouracil and Cd on Seed Germination of Wheat, Chinese Cabbage and Rice |
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| KeyWord:5-fluorouracil; Cd; combined contamination; ecotoxicity; seed germination |
| Author Name | Affiliation | | YUN Ye | College of Forestry Resource and Environment, Nanjing Forestry University, Nanjing 210037, China | | LI Wei | College of Forestry Resource and Environment, Nanjing Forestry University, Nanjing 210037, China | | ZHANG Yin-long | College of Forestry Resource and Environment, Nanjing Forestry University, Nanjing 210037, China | | QIAN Jing | College of Forestry Resource and Environment, Nanjing Forestry University, Nanjing 210037, China | | WANG Yue | College of Forestry Resource and Environment, Nanjing Forestry University, Nanjing 210037, China |
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| Abstract: |
| An acute toxicity experiment was designed to examine the effects of single and combined contamination of 5-fluorouracil, a typical anti-cancer drug, and cadmium on seed germination of wheat, Chinese cabbage and rice. Under single contamination, the inhibition rates of root and shoot elongation of three crops significantly correlated with concentrations of 5-fluorouracil and Cd（P<0.05）, and the inhibition rates by 5-fluorouracil and Cd were greater in the roots than in the shoots. The median inhibition concentration（IC50） of 5-fluorouracil and Cd to the root elongation of wheat, Chinese cabbage and rice were 212.80 mg·L-1, 102.53 mg·L-1, and 13.30 mg·L-1, and 118.27 mg·L-1, 23.32 mg·L-1 and 22.21 mg·L-1, respectively. The sensitivity of three crops to 5-fluorouracil and Cd was in sequence of rice>Chinese cabbage>wheat. Combinations of 5-fluorouracil and Cd showed less inhibition to root elongation than the addition of the individuals, implying that combined 5-fluorouracil and Cd had antagonism. |
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