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| Effects of albendazole on biochemical characteristics of earthworms |
| Received:December 31, 2015 |
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| KeyWord:albendazole;earthworm;antioxidant enzyme;glutathione-S-transferase;malondialdehyde;biomarker |
| Author Name | Affiliation | E-mail | | CONG Lin | College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China
College of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China | | | WU Rui | College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, China | 19393603@qq.com | | LI Yin-sheng | College of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China | |
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| Abstract: |
| The toxicity of albendazole (ABZ) was investigated using earthworms and artificial soils contaminated with varying concentrations (0, 50, 100, 200, 400 and 600 mg·kg-1) of ABZ. The toxicity to the earthworms was assessed by measuring malondialdehyde (MDA) con tent and glutathione-S-transferase (GST), superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activities of earthworms after exposure to ABZ for 3, 7, 14 and 28 days. The MDA content was positively correlated with ABZ concentrations; Such correlation was signifi cant at ABZ concentration of 400 mg·kg-1 after 3 days and 600 mg·kg-1 after 3, 7 and 14 days. The activities of SOD, CAT, POD and GST were negatively correlated with ABZ concentrations. The SOD and CAT activities were significantly inhibited by ABZ at 600 mg·kg-1 after 14 days, while POD activity was significantly suppressed by 600 mg·kg-1 after 7 days, and GST activity by 400 to 600 mg·kg-1 after 14 days. These sensitive biochemical indexes may be used as ecotoxicological biomarker of albendazole. |
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