| 邓兆荣,王 猛,管 磊,慕 卫,刘 峰.日本鹌鹑对吡虫啉的毒性效应响应[J].农业环境科学学报,2013,32(8):1529-1536. |
| 日本鹌鹑对吡虫啉的毒性效应响应 |
| The Toxic Effects of Imidacloprid on Japanese Quail |
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| DOI：10.11654/jaes.2013.08.006 |
| 中文关键词: 吡虫啉 日本鹌鹑 毒性 毒理效应 |
| 英文关键词: imidacloprid Japanese quail toxicity toxicological effects |
| 基金项目: |
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| 中文摘要: |
| 以日本鹌鹑为试验生物，采用经口服和饲喂两种染毒方式，测定了其对吡虫啉的急性和蓄积性毒性的响应，并结合血液生化指标评价了其对吡虫啉的亚慢性毒理效应。结果显示，吡虫啉对日本鹌鹑的急性经口LD50为30.25 mg·kg-1体重，毒性等级为高毒；急性饲喂LC50为1 455.11 mg·kg-1饲料，毒性等级为低毒；吡虫啉对日本鹌鹑的蓄积系数K＞5，属于轻度蓄积。亚慢性毒性试验后期，中、高浓度处理组的雌、雄鹌鹑体重、耗食量均明显减少，血液血清生化指标中血肌酐（CREA）和尿酸（UA）与空白对照组相比显著升高；高浓度处理组的鹌鹑肝脏脏器系数极显著（P＜0.01）高于空白对照组。 |
| 英文摘要: |
| The acute and accumulation toxicities of imidacloprid on Japanese quail were determined by oral way or feeding exposure method, and the sub-chronic toxicological effects of imidacloprid were also evaluated according to the blood biochemical indicators. The results showed that the LD50 of oral acute toxicity was 30.25 mg·kg-1 bw, it belongs to high toxicity grade. The dietary LC50 was 1 455.11 mg·kg-1 feed and the toxicity level is low grade. The cumulative coefficient（K） was greater than 5, which belongs to a low-grade accumulation. At the later of sub-chronic toxicity period, the weight and food consumption were significantly reduced with the treatment of the middle and high concentration. The serum creatinine and uric acid of blood serum biochemical parameters were significantly increased compared with the control group. The liver organ coefficient of the treated quail with the high concentration was higher than the control group（P<0.01）. The maximum no-effect level（MNEL） of imidacloprid on Japanese quail was 29.10 mg·kg-1 feed, and the minimum effect level（MEL） was more than 72.76 mg·kg-1 feed. The main target organ of imidacloprid on the Japanese quail was liver and it was also harmful to kidney in a certain extent. |
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